She made her feature directorial debut with 'Queen & Slim', which she also produced. In television, she served as executive producer and director on HBO’s critically acclaimed series 'Insecure' and directed the Emmy-winning 'Thanksgiving' episode of 'Master Of None'.

Matsoukas’ distinctive visual style and intuitive storytelling have also led her to direct global campaigns for major brands including Adidas, Beats, Calvin Klein, Stella McCartney, and Nike. Prior to shaping powerful brand narratives, she directed projects for some of the biggest names in music and entertainment, including Rihanna, Jay-Z, Lady Gaga, Solange, Snoop Dogg, Pharrell, and Beyoncé.